Skip to content
Fertility and Lupus
avatar
R Swamy Venuturupalli, MD, FACR posted:
Fertility is usually normal in Lupus patients, however, several circumstances may affect fertility such as drugs, dialysis and disease activity.

If the disease is very active, patients can have irregular periods or none at all, as this is the body's reaction to stress. Once the disease is under sufficient control, menstrual regularity is restored. A third of patients have significant kidney disease, which often evolves into end-stage renal disease, which requires dialysis over a 10 year observation period. Dialysis is related to poor or no menstrual cycles. A successful kidney transplant would therefore restore regular periods. Furthermore, some chemotherapy drugs interfere with ovulation. Premature menopause is caused by Cyclophosphamide in upto half of the women in their 20's who take it for at least a year, and upto 80% of women who take it in their late 30's. Methotrexate, Azathioprine, Cyclosporine and nitrogen mustard are not related to loss of periods in women with Lupus. A few women need to be made hormonally "prepubertal" with leuprolide (Lupron) and need to take cyclophosphamide, which is akin to having their eggs removed and stored for use at a later date.

In terms of male fertility, men who take chemotherapy have decreased sperm counts. Sterility is uncommon. It's advisable for men to store (bank) their sperm before commencing treatment.
Was this Helpful?
2 of 2 found this helpful
Reply


Featuring Experts

Dr. R. Swamy Venuturupalli is a board-certified rheumatologist practicing in Los Angeles. He is Clinical Chief of the Division of Rheumatology at Ce...More

Coping
With Lupus

WebMD's Day2Night will help you develop personal coping strategies for living with lupus – at home,
at work, or with family
and friends.
Visit Lupus Day2Night

Helpful Tips

Hives & Rashes
I was just reading your post about hives. Egyptian Magic is amazing! It will almost always take them. It also helps with the pain itching ... More
Was this Helpful?
6 of 13 found this helpful

Related News

There was an error with this newsfeed

Related Drug Reviews

  • Drug Name User Reviews

Report Problems With Your Medications to the FDA

FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.