Skip to content


    Exciting News for WebMD Members!

    We've been busy behind the scenes building new message boards for you. You'll have new and easier ways to find messages, connect with others, and share your stories.

    And, this will all be available on your smartphone or other mobile device!

    What Do You Need to Do?

    The message board you're used to will be closing in the coming weeks. While many of your boards will be making the move to our new home, your posts will not. Want to keep a discussion going? Save posts you want to continue (this includes your member profile story), so that you can re-post them in the new message boards.

    Keep an eye here and on your email inbox, we'll be back in touch soon to give you all the information you need!

    Yours in health,
    WebMD Message Boards Management

    Fertility and Lupus
    R Swamy Venuturupalli, MD, FACR posted:
    Fertility is usually normal in Lupus patients, however, several circumstances may affect fertility such as drugs, dialysis and disease activity.

    If the disease is very active, patients can have irregular periods or none at all, as this is the body's reaction to stress. Once the disease is under sufficient control, menstrual regularity is restored. A third of patients have significant kidney disease, which often evolves into end-stage renal disease, which requires dialysis over a 10 year observation period. Dialysis is related to poor or no menstrual cycles. A successful kidney transplant would therefore restore regular periods. Furthermore, some chemotherapy drugs interfere with ovulation. Premature menopause is caused by Cyclophosphamide in upto half of the women in their 20's who take it for at least a year, and upto 80% of women who take it in their late 30's. Methotrexate, Azathioprine, Cyclosporine and nitrogen mustard are not related to loss of periods in women with Lupus. A few women need to be made hormonally "prepubertal" with leuprolide (Lupron) and need to take cyclophosphamide, which is akin to having their eggs removed and stored for use at a later date.

    In terms of male fertility, men who take chemotherapy have decreased sperm counts. Sterility is uncommon. It's advisable for men to store (bank) their sperm before commencing treatment.
    Was this Helpful?
    2 of 2 found this helpful

    With Lupus

    WebMD's Day2Night will help you develop personal coping strategies for living with lupus – at home,
    at work, or with family
    and friends.
    Visit Lupus Day2Night

    Helpful Tips

    Minimizing steroid side effectsExpert
    It is likely that most lupus patients will at some time be taking steroids to control some aspect of their disease. In order to minimize ... More
    Was this Helpful?
    79 of 110 found this helpful

    Related Drug Reviews

    • Drug Name User Reviews

    Report Problems With Your Medications to the FDA

    FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.