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Use of Clomid for Male Infertility or Low Sperm Production
AmyAALC posted:
Clomiphene Citrate, or more commonly Clomid, has been found to improve semen quality and thus increase subsequent pregnancies in men with low to low-normal testosterone levels and low sperm production.

Protocol: Clomid protocol for managing substandard post reversal semen analysis sperm density parameters.

Indications: Following a microsurgical vasectomy reversal, there are occasions where the post reversal semen analysis sperm density parameters are lower than anticipated. Possible explanations include low to low-normal testosterone within the testicles. Successful management of this can be achieved with a regimen of Clomid.

Candidates: Patients who have had a vasectomy reversal and who after review of the semen analysis have finding suggestive of low sperm production.

Rationale: It is known that low natural testosterone levels can lead to low sperm production.

Treatment: The recommended dose and duration of treatment is 25-50 mg per day or every other day for at least two months. Some data suggest that every-other-day dosing regimen is more effective. Semen analyses and if indicated, a testosterone assays should be performed to monitor effectiveness of treatment. A semen analysis should be preformed after the medication has been taken for two months. If semen quality improves, continuation of the Clomid may then be recommended beyond the initial two-month duration, with a semen analysis performed at two month intervals for the duration of treatment.

Adverse Effects: Though uncommon, the use of clomiphene citrate in treating male factor infertility has been associated with dizziness, headache, abdominal discomfort, mouth ulcers, rash, abnormalities of glucose tolerance and gynecomastia. If any of these side effects are notice discontinue use immediately and report symptoms to the ordering physician.

Information on Clomiphene Citrate use for treatment of male infertility was provided by the American Society of Andrology Position Statement 03/09/09.

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