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Bioidentical pellet hormone replacement therapy in women
An_251754 posted:
I am a 61 year old post menopausal woman on hormone replacement ppellet therapy for about a year. I have experience relief of all of my menopausal symptoms and am enjoying a reved up and renewed libido. Please send me some true facts about this therapy and the risks involved. My understanding is that this form of therapy (bioidentical) carries far few risks than conventional hormone replacement therapy. I ham hearing some conflicting comments.

Mary Jane Minkin, MD responded:
Dear An_251754,
The major advantage that transdermal, non oral hormone therapy has is that it seems to have a lower risk of leading to blood clots, which is a good thing. Transdermal estrogens and oral estrogens have the same small risks of breast cancers when used for many years. I do not recommend pellet therapy, because most women get significant surges of estrogen when their pellets get inserted; and the pellet effects wear off unevenly. I usually would encourage you to consider switching to a transdermal patch, where estrogen levels are truly more "level"-without significant surges. And the transdermal patches are also bioidentical, and plant derived. And if you still have your uterus, you can also get bioidentical progesterone in the form of Prometrium, which is also available from a regular drug store.
Good luck,
Mary Jane

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