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    An_251767 posted:
    I have been on Prempro for 16 years with no problems and feel great. Do have a history of bone loss in my family. Because of going on Medicare, the cost is no longer covered by insurance. It was suggested that I change to a combination of Esrradiol and Provera which is only a few dollars. I am willing to pay for the Prempro. Yes, it is a huge savings, but I am not willing to risk messing with my body and changing things after all this time. Don't know what to do. Would appreciate some advice.
    Mary Jane Minkin, MD responded:
    Dear An_251767,
    First question I will ask: are you on the lowest dose of Prempro? the reason I ask is that the North American Menopause Society recommends that folks take the lowest dose consistent with treatment goals, and the lowest dose will give you bone protection. I trust you are discussing your ongoing use of hormone therapy with your health care provider. Indeed, a dose of 0.5 mg of estradiol and 1.25 mg of provera would be ballpark equivalent to the lowest dose of pPrempro; and if that works out much less expensively, it is totally reasonable to give it a try. It should give you comparable bone protection to the lowest dose of prempro. You could try it and see how you feel; it is reasonably close to the lowest dose of prempro.
    Good luck,
    Mary Jane

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