Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up


All communities will be placed in read-only mode (you will be able to see and search for posts but not start or reply to discussions) as we conduct maintenance. We will make another announcement when posting is re-opened. Thank you for your continued support and patience, and if you have any further questions, please email

Yours in health,
WebMD Community Management

Includes Expert Content
Peri-Menopause and Fibroids
4midlife7 posted:
Dr. Minkin:
I hope you can help. I am a 47 yr old in the throes of peri-menopause. Diagnosed with Fibro-Cystic disease in 1996 -- occasional ovarian cysts, but no problems. Irregular bleeding (in time and flow) started early 2012. My physical med history is good with HCTZ 25 mg controlling BP since 2009 and all labs well within their prospective ranges. Since 2009 my regular physician has done my paps with no problems. Since the peri-craziness started last year, I decided that this year I would go to a female OB-GYN to see, if possibly, their were some things that could be done to control the symptoms (mood swings, sleeplessness, no libido, etc.). Let me note that my regular doctor says no to hormones and I agree. I was actually very disappointed with OB-GYN. She had a litany of things for me to do, but I didn't like much of it. It included Effexor, Estratest (low dose bc), an ultra sound and pelvic exam (vaginal probe w/camera) and histological biopsy. No Effexor-I do not want to mess with my body chemistry like that. No hormones and I'm a moderate smoker. The imaging (including mammo) I did gladly and fibroids were discovered. The histo/biop, I have not completed. My normal annual physical was in June and this occurred in July. My lab work was excellent in June. Is it really necessary to have another camera look-see and biopsy? I feel fine and exercise often, but I am just not comfortable doing the histo/biop. If I had one symptom that I would like to control, would be the bleeding. It can be excessive at times, but it will also disappear for 8 or 9 weeks at a time. Thank you so much for your time.
Mary Jane Minkin, MD responded:
Dear 4midlife7,
I hope I can help. The bleeding pattern does sound classic perimenopausal. Of course, strange bleeding can also be a sign of abnormalities in the lining of the uterus. One way to try to avoid a biopsy: did she comment on the width of the lining of your uterus? Was it 5 mm or less? And was the ultrasound done right after a bleed? In general, if the lining of the uterus (so call endometrial echo) is 5 mm thick or less, it would be very unusual to have significant pathology in the lining (such as hyperplasia or cancer). If it was thicker but not right after a good clean out bleed, I would suggest you take some progestin to help clean things out (totally safe), and then remeasure the lining. If it thick, then it is reasonable to do a sampling of the lining. One way to manage bleeding in the perimenopausal time frame is to periodically take some progestin, to induce a clean out bleed (what is happening is that you are still making some estrogen, but not ovulating super well-and we make our progesterone when we ovulate)-and the easy way to think of progesterone is the policeman (or lawn mower ) of the lining of the uterus (thinking of estrogen as the fertilizer for the lining of the uterus-as eloquently described by Professor Nanette Santoro). Another option to control bleeding in the perimenopause is to insert a Mirena IUD-which is coated with progestin, and it keeps the lining of the uterus thin. There are two bioidentical progesterone products available: one is a pill called Prometrium and the other is a vaginal gel known as Crinone, which are both bioidentical plant derived progesterone.
One suggestion: you didn't mention hot flash symptoms; but there is good data available showing that smokers have worse hot flashes than non smokers; so working on stopping smoking can also benefit menopausal symptoms.
Good luck,
Mary Jane

Featuring Experts

Mary Jane Minkin, MD, is a nationally recognized obstetrician gynecologist, with a special interest in menopause. Dr. Minkin is clinical professor of ...More

Helpful Tips

Menopause - Younger Ages
For those of you out there that are going/gone through menopause at an early age, Yes it happens. It's unusual but it happened to me. I ... More
Was this Helpful?
21 of 32 found this helpful

Related Drug Reviews

  • Drug Name User Reviews

Report Problems With Your Medications to the FDA

FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

For more information, visit the North American Menopause Society website