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Avodart vs. Flomax?
ajk1962f posted:
A family member has BPH. He has been taking Avodart for a couple of years, but he says he doesn't see a noticeable improvement in his condition. (He also takes an OTC prostate supplement which is okay with his doctors.)

Recently he was in the hospital for an unrelated condition, and they had to give him Flomax for his BPH because they didn't stock Avodart. I suggested to him that he should ask his urologist if he could try the Flomax for a little longer to see if it helps him better than the Avodart has.

Anyone have any experience with one of these two meds working better than the other? Thanks in advance.
Sheldon Marks, MD responded:
The Avodart and Flomax are totally different medications and work through completely different mechanisms. Avodart, like Proscar, are called 5 alpha reductase inhibitors and they work over time to slowly shrink the prostate. This happens by blocking the conversion of testosterone to DHT, the much more hormonally active metabolite of testosterone.

Flomax, like Rapaflo or Uroxatral, are called alpha blockers, which work rather quickly by relaxing the smooth muscles that are in and around the prostate.

Most men get great results with one medication from each category- one to shrink the prostate gland (slow acting) and one to relax the muscles ( fast acting).
ajk1962f replied to Sheldon Marks, MD's response:
Thank you, Dr. Marks. I'll let my family member know.
Sheldon Marks, MD replied to ajk1962f's response:
Just found out that the combination of Avodart and Flomax is so good that a new drug is about to be released that is a combination of the two.
ajk1962f replied to Sheldon Marks, MD's response:
Hi Dr. Marks,

Thanks for the info. A little update: My family member was recently hospitalized for an unrelated condition. His attending physician (his internist's backup) put him on Proscar in addition to the Avodart. I thought this was a little odd, since you said that Avodart and Proscar are in the same category.

He hasn't been able to take the Pro-Sterol supplement consistently, because some of the hospital's nurses, etc. weren't aware that his doctor approved it, and they confiscated it from him.

Also, they had to insert a catheter to monitor his urine output, because the inflammation of the prostate was making this difficult for him. It's my contention that if they'd allowed him to take the Pro-Sterol as the doctor allowed, he wouldn't have such a problem.

I'm working with the hospital to get the Pro-Sterol matter straightened out.

Thanks again.
ajk1962f replied to Sheldon Marks, MD's response:
I'm happy to report that the hospital staff are finally giving him his Pro-Sterol again. Hopefully it will make a difference enough for him to not need the catheter soon.
Krisbboodoo replied to Sheldon Marks, MD's response:
DR. Mark.

I had Surgery two years ago to corroect the swelling around my bladderneck /prostate.
the problem has pop up again . i am taking avodart every night for the pass three weeks, but i am not getting much releif.
i am also take a flomax. there is a slight improvement.
i am getting a increase to the flow not much to talk about .
i am also getting a sight burning like if two areas are touching .
apart form these medication . what else can i use to reduce the swelling . what is the time frame for the problem to subside.
dlsnyder7 replied to Sheldon Marks, MD's response:
Hi Dr.Marks. GSK makes Avodart. Also available is a drug called Combodart and one called Duodart. These are combinations of dutasteride / tamsulosin hydrochloride, the active ingredients in Avodart and Flomax. The combination appears to be effective in treating acute urinary retention (determined from recently found online medical information). Personally I have been using the generic version of Flomax, Tamsulosin hydrochloride. for several years to treat this condition. The drug's effectiveness seems to vary from great to so-so, between several producers. Are Combodart and/or Duodart the drug you mentioned in this expert response you posted 5 years ago? If so, what results (successful) of the combination drug have you found since you wrote this response? Have you viewed any substantial research on the combo drugs that you can recommend to people with this problem? Thank you

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