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There are very few studies of supplements for headaches, but there are 2 or 3 things that do have pretty good evidence for migraine prevention:
Vitamen B2 (riboflavin)---this works OK for headache prevention, but you have to take 200 mg twice a day for it to work. There was a clinical trial in 1996 that showed this was better than placebo at migraine prevention.
Butterbur Root Extract (also called Petadolux, plant name is petasites hybridus)--There was a nice stude in 2004 that showed this was effective for migraine prevention. The dose is 50 mg 3 times a day (or 150 mg/day). This occasionally causes an upset stomach, but I have not had other complaints of side effects from patients.
Co Enzyme Q10: This had a nice study done in 2004 showing it was effective for headache prevention. Unfortunately they used a form not on the marked. I've suggested using 100 mg 2 or 3 tiems a day to patients. This medication is kind of expensive, so not very many of my patients have tried it.
I just read about butterbur for the first time today. One website said it can cause liver toxicity and can be carcinogenic. It also said to get it PA free. What do you think of this? Also does this help with tension headaches also as I have both. Is it something you take for the rest of your life if it works?
But you know, if they actually did a STUDY, and on a supplement or herb, that's refreshing because they aren't doing enough of those on that type of thing. The whole reason nobody knows whether something will help or not is because the Feds don't do studies on them. You could get one herb from one company and the same herb from another, and not be sure you got the same dose, or whether they picked it at the right time, etc.
I might go back and get the Co Q, and try it again if they did a study on it, hopefully it was double-blind.
You sound like me. It seems like I have tried everything and nothing helps herbally. Tried the riboflavin too, feverfew, CoQ10 and none help. I just wondered if butterbur helped many and about side effects. I take anti-inflammatories already along with a muscle relaxant when I am having a real bout of migraines and headaches so maybe the butterbur would be too much. Even things to get rid of tension headaches and migraines don't do much for me. I guess I should be happy the more expensive things for migraines don't work since $19 a pill which does not always work is a rough thing to do.
Thanks for the info.

Any help would be appreciated as he is very sedentary and in front of the computer daily reading since the headaches started about 6 months ago. He just had an eye exam and it was good and did not need new glasses.
He also uses a C-PAP at night and don't know if it is working correctly and want to make sure it is ok. It seems a lot of air is coming out around the mask he wears and think it needs to checked but do not know what to check for. Could it cause some of the headaches he is having if it is not working correctly?
Much of the time migraines aren't caused by anything except hereditary issues. The best thing to do is to work with your dr, and if he or she can't help you, ask for a referal to a headache spec/neurologist who can help quite a bit in most cases.
We are going to change his doctor for the next appointment and see if they will try to find out what is causing the headaches. The one he has now did not know what was wrong and gave him the stronger medication. If they will take time and explain the medication and what to look for would be much better and we could get a better understanding on what to expect with the medication.
And as to someone else's concerns about stomach pain. That should be avoided if you take it with a meal. I only had stomach pain one time when I didn't take it with enough food.
And it has improved my migraines.
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