Skip to content


    Attention All WebMD Community Members:

    These message boards are closed to posting. Please head on over to our new WebMD Message Boards to check out and participate in the great conversations taking place:

    Your new WebMD Message Boards are now open!

    Making the move is as easy as 1-2-3.

    1. Head over to this page:

    2. Choose the tag from the drop-down menu that clicks most with you (and add it to any posts you create so others can easily find and sort through posts)

    3. Start posting

    Have questions? Email us anytime at

    Includes Expert Content
    MS and Leg Burning
    whitefrazier posted:
    I am recently diagnosed with MS and have been on Copaxone for just a month now. My symptoms have been increasing. Now the burning in my right leg is getting out of control. All day and all night long. My legs also stay cold as ice. I have to keep leg warmers on or a blanket on all the time. What can I do? Has anyone else had this problem?
    Rory26312 responded:

    This is one for your neuro and or MS lifelines (the Copaxone support people) because if it is not a side effect itmay be a new symptom which may mean you need to have things reviewed .

    I don't usually advice this but if it persists over the weekend and your not getting any answers you may need to visit the ER if it gets worse.

    Sorry not to be of more help but I hope you feel better,

    jus4di41 responded:
    I was dx almost 6 years ago. MS affects the left side of my body and my LEGS. I can't tolerate cold weather, such as using a blanket on my legs when I drive, in restaurants, doctor offices, church, etc. the colder it gets the worst it is. I know what it feels like when you say your cold to the bone. I talked to someone recently and suggested that when we get this cold feeling, is to drink plenty of hot liquids this will help. Sometimes i get so cold I can't even drive the car. I use long underwear, sock for hunters for 35 and below and nothing warms me up, i stay cold from the thighs down. i was on copaxone, before and now on Avonex. I hope this help know that you are not alone, in feeling the way you do, hold on spring is coming. I get so cold that I walk like Frankstein. Sometimes I get so cold it hurts, I have to take a pain pill to ease the discomfort
    arealgijoe replied to jus4di41's response:
    AS MSers we are at increased risk of subclinical hypothyroidism. That can lead to being COLD. My basal body temp runs low, so I realy feel it.

    Sometimes I get a patch of leg skin that FEELS like its burning, but it does not last long.

    beckym2005 replied to arealgijoe's response:
    UGH - I get the same burning feeling too. Nice to know i'm not crazy. I dont understand how my hands and feet are freezing and my upper thigh on fire? Im on Betaseron so i'm thinking its a ms thing and not a med thing.

    kshah0512 responded:
    I have had this issue in the past. My neuro put me on neurontin and baclofen for the burning sensation and tremors. If you are not taking these meds talk to your neuro. My dosage was adjusted several times before it was under control. Good luck!
    flgirl82 responded:
    I think copaxone takes a while to get into your system. I am not quite sure but I heard it is like 9 months. My legs did that for a while and my doctor gave me a drug called Baclofen. Call your doctor and let him know what is happening. He might have a better suggestion.
    whitefrazier replied to kshah0512's response:
    thanks I will ask my neuro about these two meds.
    whitefrazier replied to flgirl82's response:
    thanks i will. Do you take it everyday?
    rajeev_jhs responded:
    please try low dose naltrixon. it is available by the name of naltima. 50 mg tablet is to be dissolved in 50 ml distilled water and take 2.5ml of this water once every night at about 10 to 11 PM. You can use the dose by keeping the liquid stored in refrigerator for upto 25 days. slowly increase the dose, but max is 4.5 ml.
    see if u feel better.
    rajeev, india
    Neil S Lava, MD responded:
    MS certainly causes sensory symptoms which can be very annoying. You need to discuss this with your neurologist since there are medications that can be used to help your symptoms.
    An_260242 responded:
    I also have same problem wqith legs
    ferret01 replied to An_260242's response:
    have taken betaseron, copaxone, and avonex never had this problem before must be ms

    Featuring Experts

    Stephanie knows multiple sclerosis as a patient and as a nurse. Stephanie was diagnosed with multiple sclerosis in 2013. Shortly after being diagnosed...More

    Helpful Tips

    Reliv does work
    I thought Reliv was a hoax too. But it's not. You need to take it regularly and consistently and it proves miracles. My mom was diagnosed ... More
    Was this Helpful?
    1 of 1 found this helpful

    Related Drug Reviews

    • Drug Name User Reviews

    Report Problems With Your Medications to the FDA

    FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.