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    An_204691 posted:
    Fatigue has been a debilitating symptom with my MS. After 5 years of taking Provigil, I have found that thyroid autoimmune disorders are quite common in patients with MS. Have your doctor test you for Hashimoto's, very specific Thyroid anitbodies. Taking low dose levoxyl has given my energy that I havent had in ages. Plus it only costs $6 month, NOT $1700+ like Provigil(for those of us that insurance doesnt cover or have hit the donut hole)
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    KeepingFaith1 responded:
    So are you saying that Provigil can cause a thyroid autoimmune disorder? I'm quite confused on why you switched. But did you find that Levoxyl is better?

    I am still experiencing tireness.

    hackwriter responded:
    Thank you for this heads-up, anon, I believe that I'm one of those who has indeed developed Hashimoto's. Recently found enlarged thyroid on an MRI--and my symptoms fulfill the criteria. TSH, T4 and T3 tests were all normal.

    I'll have an ultrasound soon, but I will ask my doc for the antibodies test as well. You were very helpful!

    By the way, I've taken Tysabri for a year (no Provigil) and I believe it has lowered my immunity to the point where it is affecting a lot of other things besides my thyroid. I'll be dropping that therapy soon.

    Kttz41 replied to hackwriter's response:
    Ask for Antithyroglb AB and Thyr Perox AB Hope it helps.
    BTW, all my basic thyroid function tests were normal too....
    Not to discourage you, but I tried Tysabri, but only for short period,WAY 2 many side effects, even thought PML after 3rd and final round. Good luck!
    Kttz41 replied to KeepingFaith1's response:
    No, I am not saying that Provigil causes thyroid issues. Im saying that in my case, once have an autoimmune disorder, seems to open Pandoras box for others. Once inquired and kept complaining of symptoms, now have Thyroid diagnosis.
    Unfortunately in todays medical world, you gotta be your own advocate.I still take both, BUT have decreased my provigil, while increased my thyroid dosage. This is all fairly new to me, but would love to be off Provigil if Levoxyl works.
    mymslog responded:
    I took Provigil and did not like the effect that it had. I was not aware that Thyroid problems were that common in MS patients. Recently my doctor tested me for possible Thyroid issues and none were detected. I am going to let her know to test for a very specific type next visit. We seem to learn more from one another then we do from Neurologist.

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