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    my hubbys creatine level is at 8.11
    sara77503 posted:
    my hubby had a liver tx 2 1/2 yrs ago , i heard profrag affects the kidneys and the dr switched him from prograf about three weeks ago to rapa, no probelms, but in the past three monhts, his creatine has went from 6 to 8.11.....................his kidney dr suggests him to go on dialysis but hubby dotn want to . or i guees i should scared at this point. i also asked the kidney dr if i could see if i am a match to donate one of my kidenys to him, or if nto i woul dbe wiling to participate in the paired donation program where i could donate one to someon ein need and someone coul donate to him.... he said that was a option, i like wish i could jsut take mine out and give it to him, we have been thru so much and now this, i am not askign why ,but i want to do wha ti can to helop if ican in a minute . has anyone been in this situation .
    John-SKPT responded:
    The damage that comes from Prograf toxicity is well established. I'm not sure though, that once the chain of events has progressed significantly, if it will have much chance of going back to where it once was. (In other words, if they had risked changing to Rapamune with the creatinine was at 3.0 rather than at 6.0, would it have made a difference? I don't know.) The decision to start dialysis is a difficult one, but in almost all cases, it is better to start sooner rather than at the last possible second. They body just degenerates more the longer that you wait. And to tolerate the potential transplant surgery, the body needs to be in the best overall condition that it can be. I can't give you any specific advice because every patient is different. But I really waited too long to start dialysis. If I had it to do over again, knowing what I know now, I think I would start a lot sooner and slow down the side effects from advancing renal disease. Good luck.

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