Skip to content


    Exciting News for WebMD Members!

    We've been busy behind the scenes building new message boards for you. You'll have new and easier ways to find messages, connect with others, and share your stories.

    And, this will all be available on your smartphone or other mobile device!

    What Do You Need to Do?

    The message board you're used to will be closing in the coming weeks. While many of your boards will be making the move to our new home, your posts will not. Want to keep a discussion going? Save posts you want to continue (this includes your member profile story), so that you can re-post them in the new message boards.

    Keep an eye here and on your email inbox, we'll be back in touch soon to give you all the information you need!

    Yours in health,
    WebMD Message Boards Management

    Long-Term SSRI Usage-Osteoporosis Link?
    kso808 posted:
    I am a 57 year-old white male who was diagnosed with severe osteoporosis (particularly in my spine) four years ago. In January 2013, I suffered my first spinal vertebrae wedge compression fracture (T-9), because of an on-the-job injury.

    I have been taking SSRI drugs for OCD for over 24 years, and there is increasing evidence that these interfere in the normal bone resorption/rebuilding process, but the jury is still out. There is only scant evidence from studies conducted about this matter, but it is gradually increasing.

    Does anyone else fall into the above situation? If so, what is your story?

    Take the Poll

    For those who have taken SSRI drugs for a long-term period of time, who is now diagnosed with osteoporosis? Particularly interested in male responses.
    • Yes, after 1-5 years of SSRI drug usage
    • Yes, after 6-10 years of SSRI drug usage
    • Yes, after 11-15 years of SSRI drug usage
    • Yes, after 16 years of SSRI drug usage
    • No, even after long-term SSRI usage
    View Poll Results
    itmatsb responded:
    I would like to point out that not being properly treated for depression leads to increased deterioration of telomeres which lead to earlier osteoporosis, stroke, heart disease and cancer. Whether there are safer anti-depressants, I don't know. I just know that I got osteoporosis well before I ever started a different SNRI anti-depressant at age 53. Plus I had a stroke at age 56. I had suffered depression for a number of years before that.

    So I might think that not taking anti-depressants could be far worse. Who knows.

    Helpful Tips

    Bisphosphonate use in premenopausal womenExpert
    The potential benefits and risks of bisphosphonate use may be quite different in premenopausal women compared to postmenopausal women. ... More
    Was this Helpful?
    24 of 34 found this helpful

    Related Drug Reviews

    • Drug Name User Reviews

    Report Problems With Your Medications to the FDA

    FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    For more information, visit the National Osteoporosis Foundation website