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Anxiety and preventing wearing off of medication
amanda578 posted:
BACKGROUND: My 87-year-old grandfather has been diagnosed with Parkinson's Disease. He is also diabetic and has a history of heart problems. He's taking Carbidopa Levopdopa (25/100 mg), Azilect, Gabapentin, Ativan, Simvasatin, Finastride, Metaforman.

PROBLEM: He's experiencing severe anxiety attacks when his levodopa medicine starts to wear off. How can we prevent these? Will taking more levodopa or the dissolve-on-your-tongue version instead help?

Many thanks for any advice.
Mark A Stacy, MD responded:
Dear amanda578,
I agree with your diagnosis of the anxiety symptoms; this is from "wearing-off" of levodopa. To help it you can try a number of things, but all are designed to keep blood levels of levodopa more stable. I would suggest you discuss doses every 4 hours with his physician - that is the average time for a levodopa pill to last in the body.

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