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    sinemet cr
    EW4567 posted:
    Dr. Stacey:
    I have been on sinemet cr for about 6 years. I recently noticed that AS SOON AS I SWALLOW IT my tremors begin or get worse, especially with the first morning dose and sometimes with the second dose. Can you explain to me why this might be happening? It only gives me relief for 4-6 hours over a 24 hr period. My only pd symptom is tremor; I don't know if its worth taking. Thanks for any help you can provide.
    Mark A Stacy, MD responded:
    Hi, EW4567
    I think your medicine schedule may be a little too far apart. Typically, Sinemet CR lasts about 4--6 hours, but this will decline over time. It also takes about 30-40 minutes to start working (or kick in). I suspect that your medicine is starting to wear off about 20 minutes before your next dose, and this leaves with you an hour gap, in which you feel your PD symptoms return. I would suggest you ask your doctor about changing your medicine dosing schedule or increasing your dose at each interval. Hope you will - this is likely an easy fix!

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