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    Anxiety sets me back
    BudBuffalo posted:
    I do fairly well mornings/early afternoons on Sinemet & Selegiline, but by evening [still on my meds> my ability to walk worsens, right hamstring muscle tightens & toes turn down. Even tho I don't "feel" anxious, I apparently have some kind of anxiety component going on which worses my PD symptoms. Is there anything I can do to combat this unnecessary anxiety? It can happen anytime, but happens especially in the evenings. By the time I get to bed my body is a mess, I have pain, tight muscles, can't walk and therefore can't sleep. Any suggestions are appreciated!
    Mark A Stacy, MD responded:
    Dear BudBuffalo,
    The symptoms you describe sound like wearing off - and occur at the end of your medication dosing. The anxiety you feel is a fairly uncommon wearing off symptom but it does occur. You may want to talk with your doctor about taking sinemet every 4 hours or add a longer acting medication like pramipexole, ropinirole or rotigotene.
    lovedogs1955 responded:
    I find that a low dose of Xanax helps me with my feelings of anxiety. I take it as needed, but usually every evening and sometimes during the middle of the night when I wake up and need to take my pain medication again.
    lovedogs1955 replied to lovedogs1955's response:
    I had an appt last week with my Neuro and we discussed the increasing anxiety and trouble sleeping. I was started on Celexa once per day with the hope of getting my anxiety and accompanying bad tremors under control. He told me it would take about 2 weeks to really notice a difference. My problems seem to always occur in the early to mid afternoon and last through the evenings. I have discussed this with other caregivers and they concur that this is more common than we think in Parkinson's.
    BudBuffalo replied to lovedogs1955's response:
    Thank you all for your input. I see my neuro this week on the 66th. Will take your suggestions with me! Hope to get some relief. My legs sre getting more aggitated when I sit down such as when to eat a meal, etc.
    lovedogs1955 replied to BudBuffalo's response:
    It has taken 3 weeks or so, but I am seeing a great improvement with the Celexa. Not needing the Xanax during the day anymore and am sleeping better at night.
    njladyluck responded:
    Hi BudBuffalo, I get anxious as well in my off periods or it is one of the first signs that I need to up the meds. I take a benadryl at night and that helps me because I have the tight muscles, restless leg syndrom. The Benedryl helps.

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