Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up


Posting to the communities has been restored. Our technical team is still completing ongoing maintenance, and you may experience some technical problems.Thank you for your continued support and patience, and if you have any further questions, please email

Yours in health,
WebMD Community Management

Includes Expert Content
2 and 1 Flea and Heartworm Triflexis ?
MSettle78 posted:
Ive been hearing alot of great information on this new Triflexis Medication which is flea and heartworm and parasite prevention for dogs and I really want to switch mine to that . Right now they are on Comfortis and Heartguard but it would save alot of money to go to just one medication that has it all. I called my vet and they dont have it yet they said they dont trust it yet but they also did this when Comfortis came out they were the last ones to sell it they are family owned so i think that could be why. Has anyone had any expierence with this whether or not its worth the change?
Bonnie Beaver, BS, DVM, MS responded:
Triflexis would be a combination drug that is equivalent to Interceptor and Comfortis combined. The only difference you would have in efficacy from what you are using now is that there would be some protection against whipworms, which are generally not a major problem in dogs.

Heartgard is used as a preventative against heartworms. Heartgard Plus adds pyrantel to help control roundworms and hookworms.
Interceptor is used as a preventative against heartworms, roundworms, hookworms, and whipworms.
Comfortis is the chemical "spinosad" for control of adult fleas and that is the same chemical that was put into Triflexis for the flea control part.

How Triflexis will be priced I do not know. I have seen companies add 2 of their drugs together and charge the amout that the 2 cost separately. It should be a good product, but as a new one, cost could be a problem.

Thanks for asking.
elliemel responded:
My vet got it in last month, and today is the second time my two dogs used it. I will not use it anymore. My dogs are a lab/shepherd mix - 65 lbs/2yrs old, and a collie/shepherd mix - 75 lbs/1 yr old. The 2 year old obviously did not feel well, I noticed last month - lethargic, wouldn't eat, etc. for about a day after taking it. But, this afternoon, within a few hours of taking the Triflexis, he began stumbling, lost his footing, and is acting very strange this evening, and I am very worried. He is sleeping now, and I will call the vet in the morning, but I am not taking any chances on this again after his not doing well two months in a row, and this time much worse. I hope this is temporary, also. Our other dog seems fine.
terrierowner replied to elliemel's response:
I used it 3 months in a row and my dog developed tremors/trembling in his legs shortly after I gave the first dose. He was also lethargic--not even 2 years old, he's not been himself so I am not going to give it to him anymore. I am going back to Heartguard and Advantage plus. I called Triflexis and they said they would replace the product at the vet so that I could get credit for it. That remains to be seen but I did purchase the meds above this weekend and will never give Triflexis to any dog again.
doglover63 responded:
Don't put your dog on Triflexis! After 2nd month my dog went into horrible seizures. Totally paralized up to 5 minutes. Vomitted,, urinated and loss of bowels during seizures. Happened 5 hours after taking and seizured off and on for hours. The company has fully reimbursed me within days of Vet reporting. That should tell you they know something is wrong with their meds. Dog has to be on downers for 30 days until this is out of his system, no quality of life for him at this time. Don't put them on Comfortis either! I'm going back to Sentinel. He was on that for years, doing just fine until vet changed it.
jerseytenn replied to doglover63's response:
I recently bought a toy poodle and upon taking her for her first vet checkup I was introduced to triflexis by the vet who said it was very safe and if she should vomit within an hr the company would refund my pill via the vet. If it was after an hr don't worry because it was in her long enough. My only concerns were she was 3lbs and 11 wks old. After being reasurred no problem I purchsed the $18 pill. I waited until she was 13 weeeks old and gave it to her. She was fine until 4 hrs later when she began to projection vomit a total of 8 times in 3 hrs. She needed a shot and special food totaling an additional cost of $39.00. All the while the vet and his assistant assured me it wasn't the triflexis. Well she was fine before it and has been fine since and I will never use it again. Incidently I wasn't offered a refund only additional expenses. This is my 7th dog and I'll go back to heartgard, its always worked in the past with no side effects.
buslett responded:
I have been using Triflexis for the past 3 months on a rescue lhasa apso. He has had no problems with this medication at all. I have not noticed any change in my dog after taking the pill. The pill costs $20/month. It is a little cheaper when buying at least 6 months worth but being on a fixed income I am not able to do that.
cbintz replied to Bonnie Beaver, BS, DVM, MS's response:
My dog was recently diagnosed with hookworms. I have given her an antibiotic given by our vet, and I will give her the second dose in 3 weeks (10lb shih-tzu). I am wondering if I should buy pet-safe antibacterial wipes and wipe her paw pads and bottom after every trip outside?

I am ultra-paranoid, and our yard is VERY large. I pick up her feces, but there are cats who roam around and various other animals.

Suggestions?! THANK YOU SO MUCH for your help with this!

Why is it that Trifexis is not preventing these hookworms from happening? We have been religiously giving her her pill each month! Thanks again!
JEMOORE replied to elliemel's response:
I'm so thankful for your comment.These symptoms sound very scary. I was debating putting my new rescue on Triflexis, but decided against it because I only use Comfortis as needed, and we've not needed it for a long time. Has anyone else discovered that Comfortis seems to continue to work long past one month? We're going to return to using our tried and true old Heartguard. Also, has anyone heard anything about the new injectable heartworm preventative that's supposed to work for 6 months at a time and is it safe?


William Draper, DVM, better known as "Dr. Will," is a well-known small animal practitioner in the Atlanta, GA area. He grew up in Inglewood,...More

Helpful Tips

Helping Hospice Patients Keep Their PetsExpert
Pets are an extremely important part of our lives. And this is especially true when we are at the end of our days. What could be more ... More
Was this Helpful?
35 of 47 found this helpful

Report Problems With Your Medications to the FDA

FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Learn more about the AVMA

WebMD Special Sections