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PSA increase after brachytherapy
An_243968 posted:
Diagnosed with prostate cancer, and had brachytherapy 15 months ago. Staging was T2b, and age is 55. Initial PSA that precipitated biopsy was 3.1, but went up to 28 and then a subsequent psa of 22 immeidately prior to brachytherapy. Dr. felt that this was likely due to a bladder infection, and went ahead with the procedure. Initial PSA's after brachytherapy were 2.8, 2.5, and 2.1. However, went up to 5.9 three months ago, and most recent PSA is 7.5. Obviously, PSA is all over the map. Will be going in this week to discuss options, but would appreciate any thoughts. PSA anxiety is working overtime.
az4peaks2 responded:
Hi an, - The first thing to do is to determine whether these elevations are due to a recurrence or represent a benign PSA "bounce". The well documented and temporary "bounce" is experienced by about one-third of men receiving Brachytherapy. It usually occurs between 1 and 2 years following the implanting of the "seeds" (ave=18 months).

Monitoring is the only way to determine the cause of post-treatment elevations and your attending Physician should be able to help you determine the actual cause. The good news is that if it does turn out to be a "bounce, rather than a recurrence, studies have shown it to have no deleterious effect on the the eventual outcome of the treatment.

Good luck! - (aka) az4peaks

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