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PSA level jumps up slightly after Radioactive Seed Implants
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Carribiancool posted:
I am a 42 yr. old who was diagnosed with Prostate Cancer back on April of 2012 my PSA level had jumped from 1.90 in 3/2011 to 2.68 on 4/2012.My Gleason score showed 3+3 in one of two cores and a 3+4 in two of two coreswith 5% of tissue on both. I decided to have Radioactive Seed Therapy because taking out my Prostate was too risky due to me having a kidney transplant. I had my PSA level checked 3 times since the implant and the first one was on 10/2012 1.98 and 3/2013 1.24 and my last one I just did it was 9/2013 1.40 so it went up just a little. Should my levels be lower like under 1.00 and should I be worried that it jumped up a little? If you have any info that can help let me know. Thanks
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MuDdLe1957 responded:
Bounces after radiation are pretty common, I am told. What you are experiencing at present is likely no cause for alarm. However, if you have a series of consecutive rises, then you will want to attend to it.

I had seeds (12/05) followed by 7 weeks of EBRT in the early weeks of 2006. I was 48 at the time. Of 12 biopsy samples, 10 were positive for cancer and an eleventh was "suspicious." The percentages ranged from 5% at the low end and very high--I'm trying to recall--like 80 or 90% at the high end. There was a bit of grade 4 in one or two of the samples, so my Gleason was 3 4. Digital exam was normal--twice.

My PSA was approaching 4.0 going in to treatment. Immediately after treatment it had dropped to 1.8. Then, as I seem to recall, it went down to something like 1.2, then back up to 1.6, hovering around there for a couple of PSA checks. I was getting nervous.

So I definitely experienced a bounce, as many patients do. At the same time I had some pretty awful urinary symptoms, including some bouts of dark blood and clots in the urine as well as urinary restriction and urgency (I fell a step or two short of the restroom a time or two). My best guess is that this was all due to residual inflammation from the radiation.

But eventually--after 18 mos or so--my PSA began to descend and my symptoms completely disappeared. The PSA went to 0.1, where it has now been for 4 or 5 years.

Happily, many of the details are now fuzzy as I have not had to think much about either the disease over the past few years.

The clinic where I was treated views treatment as successful if the PSA drops to 0.2 or less and stays there. Here's hoping that this is where you are headed!

Cheers!
 
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Carribiancool replied to MuDdLe1957's response:
Thanks for sharing your experience with me, I am hopeful from all the info you gave me and from what the doctors have said before I had the seed implant. I am looking forward to the day my PSA will drop below 1.0 and into single digit numbers.


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