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    Includes Expert Content
    Methotrexate and B-12?
    Marzipana posted:
    I take Methotrexate and folic acid. Is there a relationship/interaction between folic acid and B-12? Or Methotrexate and B-12? I seem to feel much better (more energy) if I take a B-12 supplement a couple times a week. However, my B-12 levels tested in the normal range (without supplementation).

    Just wondering...
    Scott Zashin, MD responded:
    We tend to have patients on MTX take Folic Acid because it may decrease the risk of side effects such as liver damage. Typically,I will check a patients B12 level prior to starting folic acid as taking this supplement may eventually mask a B12 deficiency. Some patients feel better on B12 and in those patients that do in my practice, I typically don't have them stop the supplement if it is oral.
    Marzipana replied to Scott Zashin, MD's response:

    Helpful Tips

    help with methotrexate side effectsExpert
    I recommend all my patients on methotrexate take at least 1 mg of Folic Acid daily to help decrease the risk of side effects. In those ... More
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