Skip to content
Includes Expert Content
Methotrexate / Blood pressure
singingbear posted:
Has anyone ever had problems with methotrexate effecting your blood pressure? Mine was up last time I saw my Rheumy (153/90). It was also the first visit after starting Methortexate. The day of my last dose (increased from 15 mg to 17.5) I had what felt like a blood pressure related headache that lasted many hours. I did not have access to a monitor to test this theory but my face was flushed and my head was pounding. I have not had a headache since that day. Before the Rheumy increased my dose I was having short mild headaches for several days after my weekly dose. At doses below 15 mg I had no problems with headaches. Just wondering if this is a problem with methotrexate anyone has experienced or if it is coincidence. I also take Prednisone which I read can increase blood pressure but this is my first high reading and have taken Pred from 10mg to 7.5mg. everyday for 3 mo.
rastable responded:
Everybody responds differently . I have taken methotrexate for 10 years and no blood pressure issues.
Scott Zashin, MD responded:
I have seen heachaches with MTX which may cause an increase in BP due to pain. I have not seen elevated blood pressures that I felt were related primarily to MTX. Nonethless, with any medication, there is always to potential to cause uncommon problems, so can't exclude a casuse and effect from MTX
singingbear replied to Scott Zashin, MD's response:
Thank you for your response. I will keep monitoring it closely.

Helpful Tips

Dry eyes and dry mouthExpert
Patients with RA may develop dryness of the eyes and mouth due to a condition called secondary Sjogrens Syndrome. The dryness is due to ... More
Was this Helpful?
39 of 46 found this helpful

Related Drug Reviews

  • Drug Name User Reviews

Report Problems With Your Medications to the FDA

FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.