Skip to content


    Exciting News for WebMD Members!

    We've been busy behind the scenes building new message boards for you. You'll have new and easier ways to find messages, connect with others, and share your stories.

    And, this will all be available on your smartphone or other mobile device!

    What Do You Need to Do?

    The message board you're used to will be closing in the coming weeks. While many of your boards will be making the move to our new home, your posts will not. Want to keep a discussion going? Save posts you want to continue (this includes your member profile story), so that you can re-post them in the new message boards.

    Keep an eye here and on your email inbox, we'll be back in touch soon to give you all the information you need!

    Yours in health,
    WebMD Message Boards Management

    Includes Expert Content
    Response needed please
    Gaskin123 posted:
    My mother has been taking methotrexate for a while now. Five pills on Sunday for RA. We have recently had to hospitalize her and found out her white blood cells are severly low. The drs are saying from the med and now giving her neuprogen. Has anyone else heard of severe decrease in white blood cells from taking methotrexate????
    singingbear responded:
    Maybe this link will help. Yes, low blood count is a possible side effect of methotrexate. A friend of mine was recently changed to a new medication because of a low white count. That is one of the things that my doctor has said he will periodically test for as well as liver function. Hope your mother is well on her way to recovery!
    Scott Zashin, MD responded:
    A low white count is a possible complication of MTX and as a result, the blood is generally monitored every 6-12 weeks. Taking daily folic acid may help. If needed, weekly folinic acid taken 8-12 hours after MTX as well as avoiding the drug during infection and with medications that might increase the levels of MTX may help prevent this problem.

    Helpful Tips

    help with methotrexate side effectsExpert
    I recommend all my patients on methotrexate take at least 1 mg of Folic Acid daily to help decrease the risk of side effects. In those ... More
    Was this Helpful?
    30 of 33 found this helpful

    Related Drug Reviews

    • Drug Name User Reviews

    Report Problems With Your Medications to the FDA

    FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.