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    Includes Expert Content
    Question about Leucovorin for side effects
    singingbear posted:
    I have RA and have been taking 17.5 mg once a week of methotrexate since February. I was recently given rx for 5mg of Leucovorin in once a week dose in addition to 2mg of folic acid daily for side effects (hair loss and horrible fatigue). I was told to take the leucovorin 8-10 hrs after my methotrexate dose. My rheumatologist said before 8 hrs it effects methorexate effectivness and after 10 hrs Leucovorin will not help. I have seen, however, multiple times on this site that leucovorin is usually to be taken 24 hrs after methotrexate. Is taking it within 8 hrs unusual? Should I be waiting to take my folic acid as well? The Rheumy has never mentioned this. Thank you for any info.
    Scott Zashin, MD responded:
    For those patients I prescribe folinic acid (leucovorin), I tell them to take it 8-12 hours after their once a week MTX dose,, If they forget, it still may help to take it in the first 24 hours to help prevent MTX side effects such as fatigue, mouth ulcers, as well as other problems. .I also keep my patients on daily folic acid 1mg.

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