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    How long does it take for Valproic acid levels to stabalize?
    avatar
    An_241654 posted:
    I'm bipolar, was on 500mg Depakote daily, but was still experiencing significant manic episodes. Doctor increased dosage to 1,000mg daily and measured my Valproic acid level 30 days later. It was very high, but just under the safe limit. She said she wanted to monitor me closely to insure no liver damage.

    However, it's been 6 months and she keeps cancelling and rescheduling my monthly appointments (now set to see her in January, unless rescheduled yet again).

    So, my question is, how long does it take for my Valproic acid levels to stabilize, so that she can get an accurate assessment of how my body is processing the 1,000mg dosage?

    Stats: Male, 53, 220lbs
    Yea I know...overweight. Blame depakote, not me
     
    avatar
    Joseph F Goldberg, MD responded:
    Dear An, a therapeutic Depakote blood level for mania corresponds to a dose of roughly 20-30 mg/kg, which for 220 pounds would roughly be 2500 mg/day. Steady-state blood levels can usually be measured 3-5 days after a dosage change. Dr. G.


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