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    Dr G lithium and depakote question
    An_260942 posted:
    I've been on lithium and depakote for about a year now and am doing well. Levels are being kept up in the high maintenance area. Haven't had any problems (knock on wood). I just had a physical and live test results came back abnormal. I was wondering if either lithium or depakote effects the liver? A couple months ago I was also started on Isozaid (sp?) for inactive tb. I know that effects the liver but I was wondering if they were interacting. Thanks.
    Joseph F Goldberg, MD responded:
    Dear An,
    Both Depakote and isoniazid can cause a rise in the levels of enzymes made by the liver. More rarely, either could cause damage to the liver as reflected by a very high rise in those enzyme levels. Generally, in the case of Depakote, enzyme levels that don't rise higher than 3x the upper limit of normal are not of great concern, and for isoniazid, 5x the upper limit of normal. Depending on how high your liver enzyme tests are, your doctor may decide just to recheck them in a few weeks to make sure they are not trending higher than they are now.
    Dr. G.

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