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    29% Reported Muscle Pain and Weakness on Statins
    avatar
    surfoahu posted:
    Somehow I missed this back in 2012.

    8918 statin patients surveyed, and 29% reported muscle pain and weakness.

    Its always better to get data straight from the horses mouth rather than a "study' funded by those with a financial interest, where this side effect is claimed to be around 1%.

    Drug studies need to be 100% blind, where parties with a financial interest have provided no funding, have no financial connections of any kind, and zero contact with the independent party conducting the study. This is the only way to get the truth.
     
    avatar
    iride6606 responded:
    8918 statin patients surveyed, and 29% reported muscle pain and weakness.


    There's your answer, simple. How was the survey written? What were the questions? Who wrote the questions? If it was designed to find zebras then they will find zebras. This is why studies can not be blind, they need to be controlled and qualify the difference between causation and non causation unless you're looking for a specific outcome.


    In a recent meta analysis done by John Hopkins looking at ACTUAL results of over 80,000 participants found;


    "At the doses tested in these 83,880 patients, only a small minority of symptoms reported on statins are genuinely due to the statins: almost all reported symptoms occurred just as frequently when patients were administered placebo. New-onset diabetes mellitus was the only potentially or actually symptomatic side effect whose rate was significantly higher on statins than placebo; nevertheless, only 1 in 5 of these new cases were actually caused by statins."



     
    avatar
    surfoahu replied to iride6606's response:
    Yes, Its industry standard to down play side effects. I wouldn't expect anything different.
     
    avatar
    billh99 responded:
    This seems to be the study that you are talking about.
    http://www.medpagetoday.com/Cardiology/Dyslipidemia/33422

    "
    The study was funded by Kowa Pharmaceuticals America and Eli Lilly.
    Cohen reported he had no conflicts of interest. Brinton reported relationships with Abbott Laboratories, AstraZeneca, Merck, Bristol-Myers Squibb, Daiichi Sankyo, Kaneka Pharma America, Takeda Pharmaceuticals, Kowa Pharmaceuticals, GlaxoSmithKline, Boehringer Ingelheim, LipoScience, Amarin Pharmaceuticals, Health Diagnostics Laboratory, Roche/Genentech, Atherotech, Essentialis, and Arisaph. Other co-authors reported relationships with some of the same companies."


    So you can't believe this study.


    But also notice this.


    "Significantly more former users had arthritis, depression, gastroesophageal reflux, osteopenia, and osteoporosis."


    Do you think that many of those people had pain/weakness before taking a statin.
     
    avatar
    iride6606 replied to billh99's response:
    Also from the study in question as I stated earlier;


    One limitation of the study is that it may not represent the overall population of the U.S., researchers said. Also, the study is limited by the potential for bias inherent in self-reporting.


    Bill, you are correct. The former participants were not broken down into sub groups and measured separately so the results are moot. But it makes a good headline, right?
     
    avatar
    surfoahu replied to billh99's response:
    Bill, I didn't realize the study was drug company funded. Now that I know of the conflicts of interest, I apologize for posting an invalid study.

    But we should never be too quick to dismiss patient complaints of muscle pain and weakness on statins. Apparently even the drug companies take the complaints seriously, or they would not have invested mega millions in an alternative cholesterol lowering drug for those who cannot tolerate statins.
     
    avatar
    iride6606 replied to surfoahu's response:
    A couple observations, first is again proving you don't read beyond the headline or that disclaimer would have jumped out at you. Wasn't it you trying to point out a blooper in a previous thread? Outstanding.


    Second, pretty sure Bill was being sarcastic.


    Please read before you post.


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