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    Once Promising Cholesterol Drug Fails...
    surfoahu posted:
    "Here we've got an agent that more than doubles the levels of good cholesterol and lowers bad cholesterol and yet has no effect on clinical events,"...
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    iride6606 responded:
    The same problem as Niacin, artificial HDL particles are less effective than naturally occurring ones, no surprise as most every drug in this class has been a failure proving again it's about lowering LDL as statins do.

    Statins are still the gold standard.
    billh99 replied to iride6606's response:
    There is more to it than just "artificial HDL". There are some people with genetic high levels of HDL that are not protective.

    It has to do with the measurement of HDL influx capacity. AFAIK there are no clinical test to measure this.
    surfoahu responded:
    The article says the drug lowered LDL by an average of 37%, yet no effect on clinical events.

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