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    Review Of Trials Dispute Warning That Statins Impair Memory And Cognitive Functioning
    avatar
    iride6606 posted:
    The evidence is finally being published. Many of us already knew this from independent review of the data. Statins simply do not impair cognitive function and a movement is out to have the mention of "a possible link" removed from statin warnings;


    Subsequent reviews of available research have cast doubts on the cautionary stance taken by the FDA. Ott's and colleagues set out to do a more comprehensive analysis using well-studied analysis methods. They scrutinized the data of 25 relevant randomized clinical trials that investigated a possible link between statin therapy and mental ability. Combined, these studies included the test results of 46,836 patients. Ott and his colleagues also contrasted and combined the results of 14 of these studies through a meta-analysis, which in total included 27,643 participants.


    The review found no significant effect of statin use on the mental capacity of either people with normal brain functioning or even those with Alzheimers' disease. The results suggest that the FDA's statin warning should be re-evaluated. Ott also believes there is a need to investigate the reasons behind the differences in the review results and the initial reports on which the FDA warning was based. It could be that some of the mental changes that were reported in the case studies were the result of overdosing with statins.



    "We found no significant effects of statin treatment on cognition," concludes Ott. "Given these results, it is questionable whether the FDA class warning about potential cognitive adverse effects of statins is still warranted.."


    http://www.science20.com/news_articles/review_of_trials_dispute_warning_that_statins_impair_memory_and_cognitive_functioning-152183

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