Skip to content

    Announcements

    Attention All WebMD Community Members:

    These message boards are closed to posting. Please head on over to our new WebMD Message Boards to check out and participate in the great conversations taking place: https://messageboards.webmd.com/

    Your new WebMD Message Boards are now open!

    Making the move is as easy as 1-2-3.

    1. Head over to this page: https://messageboards.webmd.com/health-conditions/f/digestive-health/

    2. Choose the tag from the drop-down menu that clicks most with you (and add it to any posts you create so others can easily find and sort through posts)

    3. Start posting

    Have questions? Email us anytime at [email protected]

    Vitamin D and Crohn's
    avatar
    everydayizagift posted:
    Vitamin D Supplements Could Fight Crohn's DiseaseScienceDaily (Jan. 27, 2010) — A new study has found that Vitamin D, readily available in supplements or cod liver oil, can counter the effects of Crohn's disease. John White, an endocrinologist at the Research Institute of the McGill University Health Centre, led a team of scientists from McGill University and the Universit? de Montr?al who present their findings about the inflammatory bowel disease in the Journal of Biological Chemistry.
    See Also:Health & Medicine Reference "Our data suggests, for the first time, that Vitamin D deficiency can contribute to Crohn's disease," says Dr. White, a professor in McGill's Department of Physiology, noting that people from northern countries, which receive less sunlight that is necessary for the fabrication of Vitamin D by the human body, are particularly vulnerable to Crohn's disease.
    Vitamin D, in its active form (1,25-dihydroxyvitamin D), is a hormone that binds to receptors in the body's cells. Dr. White's interest in Vitamin D was originally in its effects in mitigating cancer. Because his results kept pointing to Vitamin D's effects on the immune system, specifically the innate immune system that acts as the body's first defense against microbial invaders, he investigated Crohn's disease. "It's a defect in innate immune handling of intestinal bacteria that leads to an inflammatory response that may lead to an autoimmune condition," stresses Dr. White.
    What Vitamin D does
    Dr. White and his team found that Vitamin D acts directly on the beta defensin 2 gene, which encodes an antimicrobial peptide, and the NOD2 gene that alerts cells to the presence of invading microbes. Both Beta-defensin and NOD2 have been linked to Crohn's disease. If NOD2 is deficient or defective, it cannot combat invaders in the intestinal tract.
    What's most promising about this genetic discovery, says Dr. White, is how it can be quickly put to the test. "Siblings of patients with Crohn's disease that haven't yet developed the disease might be well advised to make sure they're vitamin D sufficient. It's something that's easy to do, because they can simply go to a pharmacy and buy Vitamin D supplements. The vast majority of people would be candidates for Vitamin D treatment."
    "This discovery is exciting, since it shows how an over-the-counter supplement such as Vitamin D could help people defend themselves against Crohn's disease," says Marc J. Servant, a professor at the Universit? de Montr?al's Faculty of Pharmacy and study collaborator. "We have identified a new treatment avenue for people with Crohn's disease or other inflammatory bowel diseases."
    This study was funded by a grant from McGill University.
    Was this Helpful?
    12 of 18 found this helpful


    Spotlight: Member Stories

    I am 21 and just was diagnose with Collagenous colitis. I was having problems for 2 years, they took out my gallbladder thinking that was it and it wa...More

    Helpful Tips

    Pamper your Bum... As often as Possible
    Most of you have heard this, but for you Newbies.. Trust me on this tip. Pamper your Bum, to keep your bum from getting raw and sore use ... More
    Was this Helpful?
    39 of 47 found this helpful

    Report Problems With Your Medications to the FDA

    FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.