Skip to content


    Attention All WebMD Community Members:

    These message boards are closed to posting. Please head on over to our new WebMD Message Boards to check out and participate in the great conversations taking place:

    Your new WebMD Message Boards are now open!

    Making the move is as easy as 1-2-3.

    1. Head over to this page:

    2. Choose the tag from the drop-down menu that clicks most with you (and add it to any posts you create so others can easily find and sort through posts)

    3. Start posting

    Have questions? Email us anytime at [email protected]

    Effexor probems & leg pain
    nene_11 posted:
    Hi All...I hope everyone is having a good day!
    I have 2 questions today. The 1st is: Has anyone taken Effexor XL where it caused immediate insomnia? My doctor started me on this at 37.5mgs two mornings ago & I have not slept since.

    The 2nd question is: I get terrible burning pain down my shins & on the tops of my feet & it feels like needles are trying to tear OUT of my skin. Its not all of the time, but often. Its not present whenever I am standing or walking-only when Im lying in bed or I have my feet up. This is not related to the Effexor as I have been experiencing these pains for some time now. Does anyone else get these pains?
    Anon_10089 responded:

    I took Effexor quite a few years ago, and yes, I do remember it causing sleep disturbances. It did get better in a couple of weeks, and I probably combatted it by upping my sleeping meds.

    Also, I think I ended up taking my second dose very early in the afternoon--around 1 or 2 pm. That also seemed to help with the sleep disturbance.

    Your leg thing sounds like it could be another fun FM symptom. Of course, if you think it's something else, you might want to see your doctor. Since it happens when you're sitting or laying down, I wonder if it's a pinched nerve or something like that? The Effexor may actually help those symptoms, but give it 6-8 weeks.

    I hope you get some sleep!
    BetteK responded:
    Sometimes we get neuropathic pain--like what diabetics get. Many of us are on Neurontin or other gabepentin meds to treat it. If this is what your doctor seems to think your problem is, you will probably be put on a similar medication.

    As with any new med, you will probably start slowly and work up to the therapeutic dose. For neurontin, that is 600mg 3 X a day or 1800 mg. It may take several weeks to work up to that dosage. Be patient.

    Hope this helps.

    CORYSGIRL30 responded:
    Hello...My doctor prescribes Effexor XR for mornings as well with her patients. However for me I find taking it at night with all my other meds works better. I guess my body is a bit *off that way...

    Have you tried Lyrica? May help with the pain, like Bette suggested.
    nene_11 replied to BetteK's response:
    Hi BetteK,
    I have already been taking Gabpentin(Neurontin) for many years now & currently take 3200mgs. Also, I tried Lyrica when it first came out & it gave me great pain relief but sadly also gave me unbearable side effects. I do not do well with SSRI's & SNRI's & think my only option is narcotic pain killers-I seem to have zero side effects from these.
    missist replied to nene_11's response:
    I think.. sounds like neuropathy-- which-- I'm wondering if it is the gabapentin.

    Sometimes things that treat something like that--in the wrong conditions can actually cause it.

    I take 600 mgs and I have little pin & needles now that I did not have before--however-- it did so much for the generalized bad feeling that I thought it was worthwhile. The pins & needles are very 'gentle' compared to other pain I had. I don't think I'd up it much though.

    good luck
    luvcali responded:
    Eventually you get used to the Effexor XL and you sleep again....and if you miss your 8 a.m. dose, by 10 a.m. you have shocks going up your neck into your head. I experienced this...and never missed my dose. took it on time. I felt better....less anxiety, which is why I was taking it.... unfortunately, I put on about 1-3 pounds a month and after 3 years.....36 months....I was up 60 pounds. Getting off of it was awful. BTW...this is my first post here. was browsing and read your post and thought I would share my experience. Good luck with it.

    Helpful Tips

    Welcome to Our FMily! My name is MeMe, I'm an FM suffer of 19 years, along with autoimmune diseases & other conditions. ... More
    Was this Helpful?
    489 of 564 found this helpful

    Related Drug Reviews

    • Drug Name User Reviews

    Report Problems With Your Medications to the FDA

    FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.