Hi folks,
Please be aware of the benefits of folate (Vitamin B9) from food, versus the risks of folic acid from supplements and fortified foods.
"Folate is a water-soluble B vitamin that occurs naturally in food. Folic acid is the synthetic form of folate that is found in supplements and added to fortified foods."(1)
The word folate comes from foliage. Folate is found in vegetables and beans, for example.
Some of the folic acid in Supplements and fortified foods, is converted by the intestines into folate. However, some of the folic acid is not converted, and circulates in the blood as folic acid. Folic acid is not naturally present in the blood. Folic acid in the blood stream may be the cause of the health problems.(2)
Lack of folate is associated with neural tube defects in infants. Folic acid supplements do prevent this. However, so does eating lots of vegetables.
Women who took folic acid supplements during pregnancy had twice the chance of dying of breast cancer, 30 years later.(4)
A 10-year study on women taking multivitamins concluded that those who took multivitamins containing folic acid increased their breast cancer risk by 20-30%.(5)
Folic acid supplementation by pregnant women was shown to increase the risk of childhood asthma by 26%.(6)
Folic acid supplementation during pregnancy is associated with increased incidence of respiratory tract infections in infants.(7)
A study of pregnant women in Sweden found an increased incidence of cardiac birth defects in women who reported using folic acid supplements early in pregnancy.(8)
Folate, the natural stuff from food, is correlated with reduced heart disease, breast cancer, colon cancer, prostate cancer and others.(3)
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Best regards, EngineerGuy
(1) http://ods.od.nih.gov/factsheets/folate.asp
(2) http://www.medscape.com/viewarticle/591111 (requires a free registration)
(3) http://www.webmd.com/heart-disease/news/20100415/b-vitamins-reduce-strokes-and-heart-disease-deaths?src=RSS_PUBLIC
(4) Charles D et al. Taking folate in pregnancy and risk of maternal breast cancer. BMJ 2004;329:1375-6
(5) http://www.ajcn.org/cgi/content/full/83/4/895
Stolzenberg-Solomon RZ et al. Folate intake, alcohol use, and postmenopausal breast cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Am J Clin Nutr. 2006 Apr;83(4):895-904.
(6) Huncharek M et al. A meta-analysis of maternal cured meat consumption during pregnancy and the risk of childhood brain tumors. Neuroepidemiology. 2004 Jan-Apr;23(1-2):78-84.
Pogoda JM et al. An international case-control study of maternal diet during pregnancy and childhood brain tumor risk: a histology-specific analysis by food group. Ann Epidemiol. 2009 Mar;19(3):148-60.
(7) Sellers TA et al. Dietary folate intake, alcohol, and risk of breast cancer in a prospective study of postmenopausal women. Epidemiology. 2001 Jul;12(4):420-8.
(8) Kim YI. Folic acid fortification and supplementation--good for some but not so good for others. Nutr Rev. 2007 Nov;65(11):504-11.