Skip to content


    Attention All WebMD Community Members:

    These message boards are closed to posting. Please head on over to our new WebMD Message Boards to check out and participate in the great conversations taking place:

    Your new WebMD Message Boards are now open!

    Making the move is as easy as 1-2-3.

    1. Head over to this page:

    2. Choose the tag from the drop-down menu that clicks most with you (and add it to any posts you create so others can easily find and sort through posts)

    3. Start posting

    Have questions? Email us anytime at [email protected]

    When should I take my PD medications?
    Mark A Stacy, MD posted:
    PD medication regimens may be as varied as the number of people with parkinson's. There are several things that are useful when organizing a medical regimen.

    First of all some PD medications last a short time. Levodopa, the active ingredient in Sinemet, lasts in the blood stream (and brain) from 2.5 to 4 hours. The controlled release form (Sinemet CR) may last up to 6 hours, but usually only 5. Levodopa competes with other protein for absorption to the blood stream, and some recommend that it not be taken with meals. I think this is not a major problem, and have my patients usually take the medication at mealtimes, and as the medication effect becomes shorter, may move to four- hour intervals (eg. 7am -11am -3pm, -7pm). Drugs that make levodopa last a bit longer include entacapone and rasagiline. (Carbidopa/levodopa/entacapone tablets are brand named "Stalevo.")

    Dopamine agonists, pramipexole (Mirapex) and ropinirole (Requip), usually last 6-12 hours, and both have recently developed once daily preparations. These new agents may be great for people who are having mobility problems in the night. I recc the once daily forms to be taken with the first dose of the day, unless night-time is difficult, and then will dose later. The original formulations are now available in generic, and may be also dosed at mealtimes - and simultaneously with levodopa.
    Was this Helpful?
    8 of 16 found this helpful
    tony32vu responded:
    I have been diagnosed with PD(pSP=progressive supranuclear
    palsy)in 2007. Since then, all Meds are ineffective. So, I used to search webs to find whomever with the same symptom like me and what meds they're taking?
    Mark A Stacy, MD replied to tony32vu's response:
    I am sorry to read that your medications are not effective; most people with PSP notice less response to drugs that PD patients. However, sometimes higher dosages may produce some benefit. I usually will try to simplify a medication regimen to only carbidopa/levodopa (25/100), and try gradually increasing to 2 tablets four times daily.

    You may wish to discuss this strategy with your doctor.

    Helpful Tips

    doctor/patient experience with rytary
    Hi- I am a cc physician who was diagnosed 6 years ago at age 41--I have not had tremor or dyskinesia but certainly have significant off ... More
    Was this Helpful?
    1 of 1 found this helpful

    Related Drug Reviews

    • Drug Name User Reviews

    Report Problems With Your Medications to the FDA

    FDAYou are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    For more information, visit the Duke Health Neurological Disorders Center